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Inhibition of CD38 by a distinct CD38 inhibitor, 78c, has been shown to elevate protein deacetylation [149]

Nano Lett

Through a targeted chemical screen, the authors identified A11, a small molecule with anti-inflammatory properties, which appears to regulate gene expression putatively by recruiting a repressive complex containing MECP2, HDAC1, SIN3A, and DNMT3A to PU.1 bound regions

Finally, the majority of mechanistic insights are derived from preclinical models, and the translation of these pathways to human pathophysiology remains incompletely elucidated